A Magistrate working in a distant outpost begins to question his loyalty to the empire.

During the marijuana bonanza, a violent decade that saw the origins of drug trafficking in Colombia, Rapayet and his indigenous family get involved in a war to control the business that ends up destroying their lives and their culture.

The story of the relationship between Karamakate, an Amazonian shaman and last survivor of his people, and two scientists who work together over the course of 40 years to search the Amazon for a sacred healing plant.